by Mark Bird | Jul 20, 2026 | News
Why does native tissue pharmacology matter? Native tissue preserves physiological receptor density, multi-receptor co-expression, endogenous signalling stoichiometry, and post-translational modifications. Compounds profiled in endogenous systems deliver data that...
by Mark Bird | Jul 15, 2026 | News
What is a neurotransmitter release assay? A neurotransmitter release assay measures the ability of compounds to evoke or modulate release of radiolabelled serotonin, dopamine, or norepinephrine from preloaded synaptosomes or transporter-expressing cells. It...
by Mark Bird | Jul 8, 2026 | News
What is ex vivo receptor occupancy? Ex vivo receptor occupancy quantifies the percentage of target receptors occupied by a drug in tissue harvested from dosed animals. It uses quantitative autoradiography to provide direct evidence of target engagement with regional...
by Mark Bird | Jul 1, 2026 | News
What role do PROTACs play in targeting tau? PROTACs are bifunctional molecules that recruit E3 ubiquitin ligases to mark tau for proteasomal degradation. They can act sub-stoichiometrically and do not necessarily require sustained target occupancy, but tau degradation...
by Mark Bird | Jun 25, 2026 | News
What is the difference between radioligand binding and SPR? Radioligand binding uses radiolabelled ligands to measure drug-receptor interactions in native membranes and tissue. Surface plasmon resonance (SPR) measures binding kinetics in real time on a sensor chip...
by Mark Bird | May 18, 2026 | News
5-Hydroxytryptamine (5-HT; serotonin) was first identified in the gastrointestinal tract and subsequently recognised as a major neurotransmitter within the central nervous system (CNS). The serotonergic system originates primarily from the raphe nuclei of the...
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