Gifford Bioscience Presents Native Tissue GPCR Research at ELRIG
We were delighted to have our Principal Investigator, Dr Sarah Routledge, presenting her latest research at ELRIG....
Ada Lovelace Day: Supporting Women in STEM
Who Was Ada Lovelace, and What Are We Celebrating? Born 10 December 1815 into the aristocratic family of the...
The Endogenous Tissue Advantage: Why Multi-Receptor Expression in Native Systems Matters for Drug Discovery
Why does native tissue pharmacology matter? Native tissue preserves physiological receptor density, multi-receptor...
Neurotransmitter Release Assays: A Pharmacological Window into Neuropsychiatric Drug Mechanisms
What is a neurotransmitter release assay? A neurotransmitter release assay measures the ability of compounds to...
Ex Vivo Receptor Occupancy: Bridging In Vitro Potency to In Vivo Drug Action
What is ex vivo receptor occupancy? Ex vivo receptor occupancy quantifies the percentage of target receptors...
Tau Pathology and Targeted Protein Degradation: How Binding Assays Support Neurodegeneration Therapeutics
What role do PROTACs play in targeting tau? PROTACs are bifunctional molecules that recruit E3 ubiquitin ligases to...
Radioligand Binding vs SPR: Choosing the Right Binding Assay for Drug Discovery
What is the difference between radioligand binding and SPR? Radioligand binding uses radiolabelled ligands to...
Serotonin (5-HT) Receptors: Classification, Signalling, Disease Roles. How to Characterise Them with Radioligand Binding and Functional Assays
5-Hydroxytryptamine (5-HT; serotonin) was first identified in the gastrointestinal tract and subsequently...
How MAO A Inhibitors Reshape Dopamine Balance
Case study: Showing how MAO A inhibitors reshape dopamine balance Context, CNS and addiction biology Service area,...
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