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Serotonin (5-HT) Receptors: Classification, Signalling, Disease Roles. How to Characterise Them with Radioligand Binding and Functional Assays

Serotonin (5-HT) Receptors: Classification, Signalling, Disease Roles. How to Characterise Them with Radioligand Binding and Functional Assays

5-Hydroxytryptamine (5-HT; serotonin) was first identified in the gastrointestinal tract and subsequently...

How MAO A Inhibitors Reshape Dopamine Balance

How MAO A Inhibitors Reshape Dopamine Balance

Case study: Showing how MAO A inhibitors reshape dopamine balance Context, CNS and addiction biology Service area,...

Cover of the Journal of Medicinal Chemistry, Volume 68, Number 15, dated August 14, 2025. The background is a solid maroon color. Centered at the top, the journal title is in yellow. Beneath the title is a rectangular image. The left side of the image contains green and blue text that appears like computer code. The right side features a cluster of orange and red molecular structures connected by yellow lines to small pods. At the bottom of

Development and Preclinical Characterization of [18F]H3-2406 and [18F]H3-2407 for Positron Emission Tomography Imaging of the Histamine Subtype‑3 Receptor – Published in Journal of Medicinal Chemistry, Vol 68 July 25

Development and Preclinical Characterization of [18F]H3-2406 and [18F]H3-2407 for Positron Emission Tomography Imaging of the Histamine Subtype‑3 Receptor – Published in Journal of Medicinal Chemistry, Vol 68 July 25

We contribute our expertise to our customer's research characterizing H3R tracers. Read the case study: Case study:...

Three vertical, transparent displays with cellular structures, each featuring three columns and two rows of circular or irregular cell groupings, with a red or blue-green color scheme in the center of the cells and white or light blue radial patterns extending outwards, mounted on metal bases, and several similar displays lying flat in the foreground with a metal ruler.

Autoradiography in Cancer Research

Autoradiography in Cancer Research

The role of autoradiography in cancer research. Autoradiography uses radiolabeled compounds to map receptor...

A man with short dark hair and a short beard, wearing clear safety glasses and a white lab coat, smiles slightly while looking towards the viewer. The background includes a window and lab equipment.

Biased Agonism, Partial Agonism and the Importance of Comprehensive Functional Screening in Drug Development

Biased Agonism, Partial Agonism and the Importance of Comprehensive Functional Screening in Drug Development

Read Dr Mark Bird's blog about the importance of measuring the G-protein in biased agonism and partial...

The title "Frontiers in Neuroscience" is in white text on a black background, with a translucent blue image of a brain in the background. Beneath the brain image, three metrics are displayed: Impact Factor (5.152), CiteScore (6.6), and Citations (182,257).

Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA, published in Frontiers in Neuroscience (vol 18, Feb 2024).

Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA, published in Frontiers in Neuroscience (vol 18, Feb 2024).

Gifford Bioscience contributes its receptor pharmacology expertise to the study of the effect of methylone...

A scientific chart comparing receptor-ligand interaction techniques. The chart is divided into columns for description, deliverables, sample/materials, and pros and cons. Rows describe different techniques including radioligand binding, receptor autoradiography, surface plasmon resonance (SPR), ELISAs, fluorescence assays, and cellular uptake & release. Each technique's pros and cons are noted, along with sample materials and deliverables such as K₁ and IC₅₀. Interspersed throughout are large, question mark speech bubbles

Which Receptor Ligand Binding Technique? Download Our Guide.

Which Receptor Ligand Binding Technique? Download Our Guide.

Not sure which technique is right your your study of receptor-ligand interaction? Download our interactive...

Celebrating the International Day of Women and Girls in Science, February 11th

Celebrating the International Day of Women and Girls in Science, February 11th

Three of our female scientists talk about what inspired them to a career in science. Video Link - Click Here...

ELRIG 2023 – We’re Exhibiting

ELRIG 2023 – We’re Exhibiting

Gifford Bioscience will be exhibiting at this year's ELRIG – Drug Discovery meeting in Liverpool on the 18th and...

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