Receptor Pharmacology and Occupancy

Radioligand Binding

Receptor Autoradiography

SPR (Biacore)

Receptor Occupancy

Cellular Uptake & Release

Gifford Bioscience Limited is a preclinical contract research organization (CRO) providing specialist services in radioligand binding assays, receptor occupancy studies, autoradiography and SPR.

At Gifford Bioscience, we employ “gold standard” radiometric methods, for maximum sensitivity and robustness, together with label-free, kinetic affinity techniques. We use cell membranes, live cells, human tissue and animal tissue.

Determination of receptor affinities and binding parameters for test compounds in a tissue homogenate or cell preparation.

Imaging distribution of a labeled test drug in tissue or organ sections.

Kinetic, label-fee measurement of a drug’s affinity for its receptor using Surface Plasmon Resonance (SPR).

Measurement of the degree to which a test compound engages its target receptor in live cells, tissues or in an animal.

Measurement of a compounds transport into cells or efflux from cells. Determination of a compound’s potency and efficacy.

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