Who We Are
Gifford Bioscience is a preclincal Contract Research Organisation (CRO). We specialize in receptor pharmacology and occupancy for neurology, oncology and metabolic diseases.
We determine receptor density, binding parameters, efficacy and receptor occupancy for your test compounds.
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Recurring customers
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US customers
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European customers
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PhD level scientists
Our PhD level scientists are experts in gold-standard radiometric methods and in advanced label-free, kinetic affinity techniques. Our customized assays use human tissue, animal tissues, cultured cells, membranes and recombinant proteins. We work with leading pharma, biotech and university researchers, worldwide.
Determination of receptor affinities and ligand binding parameters for test compounds in a tissue homogenate or cell preparation.
Imaging the distribution of a labeled test drug in tissue sections. Quantification of ligand binding in regions of interest.
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Measurement of the degree to which a test compound engages its target receptor in tissues or in an animal.
Measurement of a compounds transport into cells or efflux from cells. Determination of a compound’s potency and efficacy.
Kinetic, label-fee measurement of a drug’s affinity for its receptor using Surface Plasmon Resonance (SPR).
Measurement of second messenger levels resulting from ligand binding. Determination of potency and efficacy of compounds and identification of agonists and antagonists.
Additional Services
as part of a core receptor pharmacology study
Ancillary Services
as part of a core receptor pharmacology study
Custom Radiolabeling
Human and Animal Tissue
ELISAs
Cell Culture & Transfections
Latest News
Development and Preclinical Characterization of [18F]H3-2406 and [18F]H3-2407 for Positron Emission Tomography Imaging of the Histamine Subtype‑3 Receptor – Published in Journal of Medicinal Chemistry, Vol 68 July 25
We contribute our expertise to our customer's research characterizing H3R tracers. Read the case study: Case study:...
Autoradiography in Cancer Research
The role of autoradiography in cancer research. Auoradiography uses radiolabeled compounds to map receptor...
Biased Agonism, Partial Agonism and the Importance of Comprehensive Functional Screening in Drug Development
Read Dr Mark Bird's blog about the importance of measuring the G-protein in biased agonism and partial...
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