Radioligand Binding
Receptor Autoradiography
SPR (Biacore)
Receptor Occupancy
Cellular Uptake & Release
Gifford Bioscience Limited is a preclinical contract research organization (CRO) providing specialist services in radioligand binding assays, receptor occupancy studies, autoradiography and SPR.
At Gifford Bioscience, we employ “gold standard” radiometric methods, for maximum sensitivity and robustness, together with label-free, kinetic affinity techniques. We use cell membranes, live cells, human tissue and animal tissue.
Determination of receptor affinities and binding parameters for test compounds in a tissue homogenate or cell preparation.
Kinetic, label-fee measurement of a drug’s affinity for its receptor using Surface Plasmon Resonance (SPR).
Measurement of the degree to which a test compound engages its target receptor in live cells, tissues or in an animal.
Measurement of a compounds transport into cells or efflux from cells. Determination of a compound’s potency and efficacy.
Get up to date with the latest Gifford Bioscience developments
by reading our blog and news articles.
Please feel free to get in contact with us…
We Are Hiring
We are looking for a Senior Scientist / Scientist to join our close knit, friendly team here in Birmingham, UK. If you have in-depth experience in receptor pharmacology, find out more about the position on our Careers page.facebooktwitterCopyright © 2021 Gifford...
Business Continuity
Our laboratory facilities remain operational under the current national restrictions, with a suite of risk mitigation measures in place. Scientists may be working from home, however, when analyzing data or writing reports.facebooktwitterCopyright © 2008 - 2020 Gifford...
“SPR Evaluation of Potential Anti-COVID-19 Therapies” poster presentation at ELRIG Drug Discovery Digital 2020
ELRIG Drug Discovery Digital 2020 is starting this week, and Dr Clare Box and Dr Kevin Thompson are going to be there, virtually, to present their research evaluating novel COVID-19 therapies through the use of SPR. ELRIG Drug Discovery DigitalfacebooktwitterCopyright...
Small Molecules, Binding to AT2 Site on ACE2, Unlikely to Prevent COVID-19 Spike Protein Binding
Angiotensin II and SARS-CoV-2 ‘spike’ protein bind to independent sites on angiotensin converting enzyme 2. We used the Biacore Surface Plasmon Resonance (SPR) technique to show that the peptide angiotensin II (AT2, that is normally truncated by the ACE2 receptor) and...
COVID-19 Decoy: ACE2 in Solution “Decoys” Spike Protein, Inhibiting Binding to Surface Bound ACE2
Using the Biacore Surface Plasmon Resonance (SPR) technique, we have quantified the kinetic receptor binding parameters for COVID-19 / SARS-CoV-2 ‘spike’ protein to the trans-membrane receptor Angiotensin Converting Enzyme 2 (ACE2). Notably, when ACE2 is pre-mixed...
Contact Us
Copyright © 2022 Gifford Bioscience Limited
Privacy Policy